Growth Regulation, Imprinted Genes, and Chromosome 11p15.5
نویسندگان
چکیده
منابع مشابه
Regulation of imprinted X-chromosome inactivation in mice by Tsix.
In mammals, X-chromosome inactivation is imprinted in the extra-embryonic lineages with paternal X chromosome being preferentially inactivated. In this study, we investigate the role of Tsix, the antisense transcript from the Xist locus, in regulation of Xist expression and X-inactivation. We show that Tsix is transcribed from two putative promoters and its transcripts are processed. Expression...
متن کاملImprinted genes, cognition and behaviour.
The idea that genes can influence behavioural predispositions and their underlying psychological determinants is becoming increasingly tractable. In this article, recent findings are reviewed on a special type of inheritance, related to the transmission of traits via what have been termed 'imprinted' genes. In imprinted genes one allele is silenced according to its parental origin. This results...
متن کاملClassification of Imprinted Genes
Diploid organisms have two copies of all genes. Each copy is inherited from one of the two parents of the organism. In most diploid organisms the genes are bi-allelically expressed i.e. both inherited copies of the gene are functional. However, a subset of mammalian genes are monoallelically expressed depending on the parent-of-origin. Either the copy inherited from the mother or the one from t...
متن کاملDelta-like and Gtl2 are reciprocally expressed, differentially methylated linked imprinted genes on mouse chromosome 12
The distal portion of mouse chromosome 12 is imprinted. To date, however, Gtl2 is the only imprinted gene identified on chromosome 12. Gtl2 encodes multiple alternatively spliced transcripts with no apparent open reading frame. Using conceptuses with maternal or paternal uniparental disomy for chromosome 12 (UPD12), we found that Gtl2 is expressed from the maternal allele and methylated at the ...
متن کاملChromosome-wide identification of novel imprinted genes using microarrays and uniparental disomies
Genomic imprinting refers to a specialized form of epigenetic gene regulation whereby the expression of a given allele is dictated by parental origin. Defining the extent and distribution of imprinting across genomes will be crucial for understanding the roles played by imprinting in normal mammalian growth and development. Using mice carrying uniparental disomies or duplications, microarray sc...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Pediatric Research
سال: 2007
ISSN: 0031-3998,1530-0447
DOI: 10.1203/pdr.0b013e3180457660